Tremendous opportunities for discovery are emerging in the biological and biomedical sciences, as well as in traditional physical and social sciences, but they will require the combined power of theory, data analysis, and simulation. In the biomedical sciences, for example, researchers are being confronted by an explosion of information from genome sequencing, gene expression profiling, proteomics, multi-electrode recording, and multiple high-resolution imaging modalities. The mission of the Center for Computational Biology is to create new computational frameworks that will enable scientists to analyze the large and complex data sets that are being generated by these new experimental technologies. Principle areas of research include biophysical modeling, development dynamics,