Postdoctoral Fellow in Biomedical Optics and Medical Physics
Department of Radiation Oncology, University of Texas Southwestern Medical Center
Location: Dallas, Texas
Salary: competitive salary and benefit
Engineering and Technology: Bioengineering
Physics: Optics and Laser
We are looking for skilled and enthusiastic candidates to fill Postdoctoral Fellow positions in the Biomedical Imaging and Radiation Technology Laboratory (BIRTLab). Our mission is to innovate, develop, and apply biomedical technology to empower cancer research. Successful candidates will be joining our team to work on one of the following projects to a) establish novel in vivo optical imaging systems for 3D in vivo cell tracking, b) radiation guidance, or c) determine the therapeutic efficacy of an emerging radiation cancer therapy, FLASH.
Specifically, the project a) involves developing an ultra-sensitive fluorescence lifetime single-pixel imaging (SPI) system to overcome the limitations of conventional imaging techniques in detecting low-level in vivo optical signals emitted from luminescent cells. The primary objective of this project is to achieve 3D in vivo cell tracking to understand the migration patterns of cancer cells and the responses of immune cells to therapeutic interventions. This will facilitate the development of cancer therapies. The project will encompass the establishment of an optical SPI system, image reconstruction algorithm, and related biological experiments.
The project b) aims to develop 3D bioluminescence and fluorescence tomography as an advanced image-guided system for enabling high-precision radiation delivery in animal models. The 3D optical tomography is expected to overocme the challenge of locating soft tissue target or tumors using conventional X-ray image, reduce radiotherapy research uncertainties, and provide quantifiable treatment outcome. The imaging capabilities of the optical tomography are particularly important at the present time when radiation is being tested not only for its efficacy as a local control agent but also as an effective modulator with other systematic therapy. This project will include the development of the tomography system, 3D optical reconstruction algorithm, and biological experiments.
The project c) aims to determine if FLASH increases the tolerance of a late-responding organ vs. radiation therapy at a conventional dose rate. FLASH radiotherapy has sparked tremendous interest in the radiation oncology community due to its potential to reduce normal tissue toxicity without compromising tumor control; however, toxicity data for late-responding organs are lacking. The findings will significantly enhance our understanding of radiation-induced toxicity in late-responding organs, facilitating the translation of FLASH-RT into clinical practice and informing the design of future clinical trials. The project will encompass the radiation dosimetry, in vivo dose and dose rate verification, FLASH system commissioning, and evaluation of biological responses to radiation.
These projects are multi-disciplinary and integrate engineering, algorithm development, optics, radiation physics, biology, and industrial components.
BIRTLab provides an outstanding environment to grow candidates toward successful careers.
Lab director Dr. Wang works tirelessly with candidates to ensure they meet their career goals. Through attentive guidance, he encourages members to think creatively and develop their own research projects. All activities are supported by extramural funding through the NIH and Texas CPRIT.
Successful members are also eligible for basic clinical medical physics training and a tuition fee waiver to enroll in a certificate program with CAMPEP-accredited courses, which covers medical physics didactic elements for people who enter the medical physics profession through an alternative pathway.
Multi-disciplinary projects, a strong research environment, and the medical physics pathway together provide a unique opportunity to prepare the candidate for careers in academia and industry, or to become a professional medical physicist in the U.S.
Candidates with established experience in computational imaging,analytical calculation, numerical algorithm, tissue optics, biomedical optical system design and development, radiation physics and dosimetry are desired. Candidates who hold Ph.D degrees in optics, physics, mathematics, biomedical engineering are encouraged to apply. Further details about the BIRTLab and projects can be found at https://www.utsouthwestern.edu/labs/birt/
Position and compensation are based on candidates’ experience and NIH scale with competitive benefits. Interested candidates should send a statement of interest, CV, and the contact of 3 references to:
UT Southwestern Medical Center is committed to an educational and working environment that provides equal opportunity to all members of the University community. As an equal opportunity employer, UT Southwestern prohibits unlawful discrimination, including discrimination on the basis of race, color, religion, national origin, sex, sexual orientation, gender identity, gender expression, age, disability, genetic information, citizenship status, or veteran status. To learn more, please visit: https://jobs.utsouthwestern.edu/why-work-here/diversity-inclusion.
About Department of Radiation Oncology, University of Texas Southwestern Medical Center
UT Southwestern is a leading academic medical center—world-renowned for its research, regarded among the best in the country for medical education and for clinical and scientific training, and nationally recognized for the quality of clinical care that its faculty provides to patients at UT Southwestern University Hospitals and clinics and affiliated institutions. With six Nobel Laureates and 22 members of the National Academy of Sciences currently on faculty, UT Southwestern is among the top biomedical research institutions in the nation and consistently ranks the No. 1 academic medical center in the world for publishing high-quality scientific research, according to Nature Index. The Department of Radiation Oncology is a leader in the development and clinical implementation of innovative treatment strategies. The Department currently has a total of 21 M.D.s and 12 medical residents. The Division of Medical Physics and Engineering currently has 27 faculty-level physicists, 8 medical physics residents, 11 full-time dosimetrists, 3 research/service engineers, 3 scientific programmers, and more than 40 postdoctoral researchers and graduate students. Research projects in the Division ...of Medical Physics and Engineering, funded by various federal and state agencies including 10 active NIH R01 grants, ranging from small-animal irradiation, PET instrumentation, medical imaging, image-guided therapy, heavy ion therapy, and automatic treatment planning to artificial intelligence.We currently provide care to over 200 patients per day with state-of-the-art machines and techniques. The clinical practice is currently in 3 buildings on the same campus. Our equipment includes 10 Varian and Elekta Linacs, one Elekta Gamma Knife Icon, 1 Accuray CyberKnife M6, 1 Varian VariSource iX HDR system, 1 superficial unit, 2 Philips big-bore 4-D CT simulators, 1 Brainlab Mobius mobile CT scanner, and Varian Eclipse. A shielded OR is equipped with an additional Varian VariSource iX afterloader to perform intra-operative HDR procedures. We also perform a spectrum of cranial and pelvic LDR and nuclear medicine procedures. A dedicated breast SBRT device, GammaPod, is also in clinical service. The Department is expanding into a fourth building in summer 2021, which will add 2 Varian Halcyons, 2 Varian Ethos, and 2 Elekta Unity systems along with a Phillips MR-simulator.
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